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Ye/Entcheva/Smolka/True/Grosu: A Cycle-Linear Approach to Modeling Action Potentials

A Cycle-Linear Approach to Modeling Action Potentials*

P. Ye, E. Entcheva, S.A. Smolka, M.R. True and R. Grosu

We introduce cycle-linear hybrid automata (CLHA) and show how they can be used to efficiently model dynamical systems that exhibit nonlinear, pseudo-periodic behavior. CLHA are based on the observation that such systems cycle through a fixed set of operating modes, although the dynamics and duration of each cycle may depend on certain computational aspects of past cycles. CLHA are constructed around these modes such that the per-cycle, per-mode dynamics are given by a time-invariant linear system of equations; the parameters of the system are dependent on a deformation coefficient computed at the beginning of each cycle as a function of memory units. Viewed over time, CLHA generate a very intuitive, linear approximation of the entire phase space of the original, nonlinear system. We show how CLHA can be used to efficiently model the action potential of various types of excitable cells and their adaptation to pacing frequency.

In Proc. of EMBC'06, the IEEE International Conference of the Engineering in Medicine and Biology Society, New York City, USA, 2006.

*This work was partially supported by the NSF Faculty Early Career Development Award CCR01-33583 and the NSF CCF05-23863 Award.