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Learning and Detecting Emergent Behavior in Networks of Cardiac Myocytes.*

R. Grosu, S.A. Smolka, F. Corradini, A. Wasilewska, E. Entcheva and E. Bartocci

We address the problem of specifying and detecting emergent behavior in networks of cardiac myocytes, spiral electric waves in particular, a precursor to atrial and ventricular fibrillation. To solve this problem we: (1) Apply discrete mode abstraction to the cycle-linear hybrid automata (CLHA) we have recently developed for modeling the behavior of myocyte networks; (2) Introduce the new concept of spatial-superposition of CLHA modes; (3) Develop a new spatial logic, based on spatial superposition, for specifying emergent behavior; (4) Devise a new method for learning the formulae of this logic from the spatial patterns under investigation; and (5) Apply bounded model checking to detect the onset of spiral waves. We have implemented our methodology as the Emerald tool suite, a component of our EHA framework for specification, simulation, analysis and control of excitable hybrid automata. We illustrate the effectiveness of our approach by applying Emerald to the scalar electrical fields produced by our CellExite simulation environment for excitable-cell networks.

In CACM, the Communications of the ACM, vol. 52(3), pp. 1-10, March, 2009.

*This work was supported by the NSF Faculty Early Career Development Award CCR01-33583 and the NSF CCF05-23863 Award.